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Unrelated BMT is feasible for adult T-cell leukemia/lymphoma treatment
(Science Letter Via Thomson Dialog NewsEdge)
Unrelated bone marrow transplantation is feasible for the treatment of adult T-cell leukemia/lymphoma.
"Adult T-cell leukemia/lymphoma (ATLL) is a highly aggressive hematological malignancy. More than 40 cases of ATLL treated by allogeneic bone marrow transplantation (BMT) from sibling donors have been reported, while there have been only a few cases of unrelated BMT for treatment of this disease," scientists writing in the journal Bone Marrow Transplantation report.
According to K. Nakase and colleagues at Ehime Prefectural Central Hospital, "We began performing allogeneic BMT from unrelated donors in 1999 to improve the outcome of ATLL patients with no suitable sibling donors.
"Eight ATLL patients underwent unrelated BMT; five received the conventional conditioning regimen consisting of cyclophosphamide and total body irradiation, while three received a reduced-intensity preparative regimen."
"Two patients died due to encephalopathy of unknown etiology on days 10 and 35, and one patient died due to progression of ATLL 25 months after BMT. Five patients are currently alive and disease-free at a median of 20 months after BMT," investigators said.
Nakase continued, "Proviral human T-lymphotropic virus type-I (HTLV-I) DNA load in peripheral blood mononuclear cells (PBMCs) was assessed in four cases before and after BMT. HTLV-I proviral DNA load was reduced significantly after transplantation."
"Unrelated BMT is feasible for treatment of ATLL. Further studies in a larger number of cases are required to determine the optimal conditioning regimen and stem cell source," the authors suggested.
Nakase and colleagues published their study in Bone Marrow Transplantation (Bone marrow transplantation from unrelated donors for patients with adult T-cell leukaemia/lymphoma. Bone Marrow Transplant, 2006;37(1):41-44).
Additional information can be obtained by contacting K. Nakase, Ehime Prefectural Cent. Hospital, Division Hematology, 83 Kasugamachi, Matsuyama, Ehime 7900024, Japan.
The publisher of the journal Bone Marrow Transplantation can be contacted at: Nature Publishing Group, Macmillan Building, 4 Crinan St., London N1 9XW, England.
Keywords: Ehime, Japan, Adult T Cell Leukemia/lymphoma, Allogeneic Bone Marrow Transplantation, Unrelated Donor, HTLV-1 Proviral DNA Load.
This article was prepared by Science Letter editors from staff and other reports. Copyright 2006, Science Letter via NewsRx.com.
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