TMCnet News
Psoriasis Market - Plaque Psoriasis & Psoriatic Arthritis Therapeutics Research Report Now Available at ReportsnReports.com(PR Web Via Acquire Media NewsEdge) Dallas, TX (PRWEB) April 20, 2014 Therapeutic Class Overview: Psoriasis – Plaque Psoriasis & Psoriatic Arthritis: Novel Oral drugs and Biologics to Change Future Treatment Paradigm market research report says that over the last decades, therapeutic options for Plaque Psoriasis (PsO) and Psoriatic Arthritis (PsA) have expanded considerably and improved patients' pain, function, and quality of life. Approved biologics fill in a critical unmet need of limited efficacy of DMARDs; however, as in most cases, one drug does not fit the bill for all the patients. The lack of targeted immune therapies other than TNF-a inhibitors in Psoriasis signals opportunities for drug developers to bring agents to market that offer treatment alternatives (Anti-IL-17, IL-13, JAK, PDE4 inhibitors, etc). Pfizer launched the first oral Rheumatoid Arthritis (RA) drug –Xeljanz (tofacitinib/ CP-690,550, JAK 1/3 inhibitor) in 2012 for pts with moderately to severely active RA who are inadequate responder or intolerant to Methotrexate (MTX) at a price almost at par with biologics. In the last couple of years, the face of healthcare has been changing due to challenges – quality and its affordability and accessibility to the providers and patients. The complete report is available at http://www.reportsnreports.com/reports/275192-therapeutic-class-overview-psoriasis-plaque-psoriasis-psoriatic-arthritis-novel-oral-drugs-and-biologics-to-change-future-treatment-paradigm.html. This research believes there is an ample room for an efficacious affordable therapy to tap the mild to moderate RA pts population where biologics have not made a dent and expects few potential launches in 2014-15 (OTEZLA – apremilast, Xeljanz – tofacitinib) and onwards. This report highlights the novel targets – oral, injectables, and topical drugs in the pipeline for the treatment of Psoriasis, compares their clinical trials data, and their commercial potential. Order a copy of Therapeutic Class Overview: Psoriasis – Plaque Psoriasis & Psoriatic Arthritis: Novel Oral drugs and Biologics to Change Future Treatment Paradigm market research report at http://www.reportsnreports.com/Purchase.aspx?name=275192. List of tables provided in this report: Approved/ Marketed Products 2 A. Psoriasis' Pipeline: Small Molecules – Oral/ Injectable B. Psoriasis' Pipeline: Topical 3 Psoriasis' Pipeline: Biologics 4 Select Late- & Mid-Stage Pipeline: Plaque Psoriasis 5 Select Late- & Mid-Stage Pipeline: Psoriatic Arthritis 6 Ixekizumab: Phase III Clinical Trial Designs 7 Brodalumab: Phase III Clinical Trial Designs 8 Clinical Data Comparison: Plaque Psoriasis – Biologics 9 A. Tofacitinib: PASI Improvement from Baseline B. Tofacitinib: Improvement in Quality-of-Life (QOL) Measures 10 Other Targets in Clinical Development for RA 11 Genes Associated with Psoriasis Susceptibility 12 Competitive Landscape: Plaque Psoriasis 13 Competitive Landscape: Psoriatic Arthritis 1 PFE's Xeljanz Launch vs. Other Recent RA Launches 2 The Structure and Function of the Cytokines IL-12 And IL-23 3 Clinical Data: ACCEPT – Head-To-Head Trial with Enbrel 4 MK-3222Neutralizes IL-23, Specically 5 Immunology and Immunotherapeutic Targets of Psoriasis 6 IL-17-Induced Signaling Pathways 7 Ixekizumab: Clinical Response (PASI And sPGA) @ week 20 17 8 Itolizumab Value Proposition with Marketed Products 9 Regulation of JAK–STAT Signaling 10 INCB39110: Response Rate - Exploratory Efficacy Analyses 11 ASP015K – Changes from Baseline in PASI at Day 42 12 PDE Inhibitors Crosstalk 13 AEB071 – PASI 75 Reductions Compared with Baseline 14 DRM02– Novel Mechanism of Action 15 DLX105 – PhIa Results (PASI Changes @ Day 14) 16 Psoriasis Treatment Ladder (Schematic) 17 US Psoriasis Market Estimation 18 Proposed Schema of the Evolution of A Psoriatic Lesion 19 Distribution of Psoriasis Severity 20 Use of Therapies Depending on the Disease Severity 21 Targeted Therapy Classi?cation Based on Pathogenesis 22 Comparison of GRAPPA and AAD Treatment Guidelines List of Figures 1 PFE's Xeljanz Launch vs. Other Recent RA Launches 2 The Structure and Function of the Cytokines IL-12 And IL-23 3 Clinical Data: ACCEPT – Head-To-Head Trial with Enbrel 4 MK-3222Neutralizes IL-23, Specically 5 Immunology and Immunotherapeutic Targets of Psoriasis 6 IL-17-Induced Signaling Pathways 7 Ixekizumab: Clinical Response (PASI And sPGA) @ week 20 17 8 Itolizumab Value Proposition with Marketed Products 9 Regulation of JAK–STAT Signaling 10 INCB39110: Response Rate - Exploratory Efficacy Analyses 11 ASP015K – Changes from Baseline in PASI at Day 42 12 PDE Inhibitors Crosstalk 13 AEB071 – PASI 75 Reductions Compared with Baseline 14 DRM02– Novel Mechanism of Action 15 DLX105 – PhIa Results (PASI Changes @ Day 14) 16 Psoriasis Treatment Ladder (Schematic) 17 US Psoriasis Market Estimation 18 Proposed Schema of the Evolution of A Psoriatic Lesion 19 Distribution of Psoriasis Severity 20 Use of Therapies Depending on the Disease Severity 21 Targeted Therapy Classi?cation Based on Pathogenesis 22 Comparison of GRAPPA and AAD Treatment Guidelines Explore more reports on the pharmaceuticals market at http://www.reportsnreports.com/market-research/pharmaceuticals/ and other reports by MP Advisors at http://www.reportsnreports.com/publisher/mp-advisors/. About Us: ReportsnReports.com is an online market research reports library (http://www.reportsnreports.com/latest-market-research.aspx) of 400,000+ in-depth studies of over 5000 micro markets. Read the full story at http://www.prweb.com/releases/psoriasis-plaque-drugs/arthritis-market-report/prweb11777386.htm (c) 2014 PRWEB.COM Newswire |