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O1 isolation enhanced with antibiotic selection technique
(Science Letter Via Thomson Dialog NewsEdge)
An antibiotic selection technique enhances the isolation of environmental Vibrio cholerae O1 with epidemic potential.
According to a study from Bangladesh, "Predicting cholera epidemics through monitoring the environment for the presence of pathogenic Vibrio cholerae is complicated by the presence in water of a large number of mostly nonpathogenic V. cholerae strains.
"V. cholerae strains causing recent cholera epidemics in Bangladesh carry the sulfamethoxazole-trimethoprim (SXT) element, which encodes resistance to several antibiotics."
"Here, we show that the use of a culture medium containing streptomycin, sulfamethoxazole, and trimethoprim (the antibiotic selection technique [AST]) can significantly enhance the isolation of environmental V. cholerae O1 with epidemic potential (p<0.001).
"The AST was also used to monitor the recent emergence and spread of a new multiple-antibiotic-resistant strain of V. cholerae in Bangladesh," S.M. Faruque and colleagues at the International Center for Diarrheal Disease Research, Bangladesh in Dhaka reported.
Scientists concluded, "The results of this study support the hypothesis that pre-epidemic amplification of pathogenic V. cholerae occurs in the human host and leads to the start of an epidemic cycle dominated by a single clone of V. cholerae that spreads rapidly through environmental waters."
Faruque and colleagues published their study in the Journal of Infectious Diseases (An improved technique for isolation of environmental Vibrio cholerae with epidemic potential: Monitoring the emergence of a multiple-antibiotic-resistant epidemic strain in Bangladesh. J Infect Dis, 2006;193(7):1029-1036).
For more information, contact S.M. Faruque, ICDDR B, Molecular Genetics Laboratory, Division Science Laboratory, Dhaka 1212, Bangladesh.
Publisher contact information for the Journal of Infectious Diseases is: University Chicago Press, 1427 E 60th St., Chicago, IL 60637-2954, USA.
Keywords: Dhaka, Bangladesh, Vibrio cholerae, Antibiotic Selection Technique, Microbial Culture, Epidemic Potential, Environmental Sample.
This article was prepared by Science Letter editors from staff and other reports. Copyright 2006, Science Letter via NewsRx.com.
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