[August 31, 2015]

InVivo Therapeutics to Present at 2015 Tissue Engineering & Regenerative Medicine International Society World Congress

InVivo Therapeutics Holdings Corp. (NVIV) today announced that the abstract "Biodegradable Neuro-Spinal Scaffold Preserves Macroscopic Spinal Cord Architecture and Allows for Neural Regeneration at the Spinal Cord Contusion Epicenter" has been accepted for presentation at the 2015 Tissue Engineering & Regenerative Medicine International Society (TERMIS) World Congress to be held September 8-11, 2015 in Boston, MA. Alex Aimetti, Ph.D., Senior Director, Medical Education and Scientific Support, will be giving the poster presentation. The abstract is co-authored by Dr. Aimetti, Richard Layer, Ph.D., Simon Moore, Ph.D., and Thomas Ulich, M.D.

Mark Perrin, InVivo's CEO and Chairman, said, "Making meaningful and significant progress in the treatment of spinal cord injury continues to be our core mission at InVivo. This progress remains the fundamental value driver for our company, and I look forward to reporting on further achievements made by our scientific and clinical teams."

About the Neuro-Spinal Scaffold

Following an acute spinal cord injury, the biodegradable Neuro-Spinal Scaffold is surgically implanted at the epicenter of the wound and is designed to act as a physical substrate for nerve sprouting. Appositional healing to spare spinal cord tissue, decreased post-traumatic cyst formation, and decreased spinal cord tissue pressure have been demonstrated in preclinical models of spinal cord contusion injury. The Neuro-Spinal Scaffold, an investigational device, has received a Humanitarian Use Device (HUD) designation and is currently being studied in an Investigational Device Exemption (IDE) pilot study for the treatment of patients with complete (AIS A) traumatic acute spinal cord injury.

InVivo Therapeutics Holdings Corp. is a research and clinical-stage biomaterials and biotechnology company with a focus on treatment of spinal cord injuries. The company was founded in 2005 with proprietary technology co-invented by Robert Langer, Sc.D., Professor at Massachusetts Institute of Technology, and Joseph P. Vacanti, M.D., who then was at Boston Children's Hospital and who now is affiliated with Massachusetts General Hospital. In 2011, the company earned the David S. Apple (News - Alert) Award from the American Spinal Injury Association for its outstanding contribution to spinal cord injury medicine. In 2015, the company's investigational Neuro-Spinal Scaffold received the 2015 Becker's Healthcare Spine Device Award. The publicly-traded company is headquartered in Cambridge, MA. For more details, visit www.invivotherapeutics.com.

Safe Harbor Statement

Any statements contained in this press release that do not describe historical facts may constitute forward-looking statements within the meaning of the federal securities laws. These statements can be identified by words such as "believe," "anticipate," "intend," "estimate," "will," "may," "should," "expect," "designed to," "potentially," and similar expressions, and include statements regarding the company's strategy and expected benefits, efficacy and future clinical outcomes of its treatments for spinal cord injury. Any forward-looking statements contained herein are based on current expectations, and are subject to a number of risks and uncertainties. Factors that could cause actual future results to differ materially from current expectations include, but are not limited to, risks and uncertainties relating to the company's ability to successfully open additional clinical sites for enrollment and to enroll additional patients; the timing of the Institutional Review Board process; the company's ability to obtain FDA approval to modify its pilot trial protocol or to conduct a future study; the company's ability to commercialize its products; the company's ability to develop, market and sell products based on its technology; the availability of substantial additional funding for the company to continue its operations and to conduct research and development, clinical studies and future product commercialization; and other risks associated with the company's business, research, product development, regulatory approval, marketing and distribution plans and strategies identified and described in more detail in the company's Annual Report on Form 10-K for the year ended December 31, 2014, and its other filings with the SEC (News - Alert), including the company's Form 10-Qs and current reports on Form 8-K. The company does not undertake to update these forward-looking statements.

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