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Innovate Biopharmaceuticals Announces Collaboration with Institut Gustave Roussy to Study Regulation of Intestinal Permeability and the Gut Microbiota using Larazotide in Immuno-oncology Checkpoint Inhibitor Failure Pre-Clinical ModelsRALEIGH, N.C., March 26, 2019 (GLOBE NEWSWIRE) -- Innovate Biopharmaceuticals Inc. (Nasdaq: INNT), a clinical stage biotechnology company focused on developing novel therapeutics for autoimmune and inflammatory diseases with its lead drug comprising a new class of medicines based on gut-restricted peptides which re-normalize the gut-epithelial barrier and the gut-liver axis, announced today it shall collaborate with Laurence Zitvogel, MD, PhD, Department of Immuno-Oncology, Institut Gustave Roussy, Villejuif, France, using larazotide acetate, Innovate’s lead drug, which is entering the first ever Phase 3 trial for celiac disease in the second quarter of 2019. Professor Zitvogel’s work focuses on intestinal microbiome dysbiosis and its effects on responses to chemotherapy and checkpoint inhibitors suggesting a nexus between the gut and immune surveillance of cancers.1,2 Her team and others have found that primary resistance to immune checkpoint inhibitors, such as CTLA-4 and PD-1 based immunotherapies, can be attributed to abnormal gut microbial composition.3 Intestinal permeability is compromised in numerous diseases where a disruption of the epithelial barrier that separates the lumen from the host’s immune system may contribute to uncontrolled inflammation. Larazotide is a gut-restricted peptide which has been shown to re-normalize intestinal permeability in various inflammatory and metabolic preclinical models. Through this collaboration, Innovate and Pr. Zitvogel seek to understand how the therapeutic effect of immune checkpoint inhibitors such as antibodies to CTLA-4 and PD-1, is modulated by blocking translocation of bacterial antigens and toxins and certain metabolites from interacting with the host immune system in pre-clinical oncology models. This emerging area of groundbreaking research looking at uncovering the role of the gut microbiome in the induction of cancer and response to immune checkpoint and chemotherapy, will be one of only four afternoon educational sessions to be held on Friday afternoon, March 29, 2019, titled “Modulating the Gut Microbiome to Treat Dysbiosis and Cancer” at the 2019 American Association for Cancer Research (AACR) Annual Meeting, at the Georgia World Congress Center in Atlanta, Georgia. Sandeep Laumas, M.D., CEO of Innovate, stated, “We are pleased to work with Professor Zitvogel to understand how larazotide’s re-normalization of intestinal permeability could affect the immune checkpoint therapeutic response in tumor models as well further help elucidate the complex interaction of the gut microbiome with the immune system in cancer.” Pr. Zitvogel, MD, PhD, Scientific Director of the Gustave Roussy Immuno-Oncology Program, said, "We need to deconvolute the delicate interactions between the intestinal epithelial cells, the mirobiome and the immune system in the gut and their consequences on tumor immunosurveillance. I am excited to study how larazotide could normalize these interactions in advanced cancer patients to optimize their therapies." About larazotide acetate for celiac disease About Innovate Biopharmaceuticals, Inc. (Nasdaq: INNT) About Gustave Roussy Forward Looking Statements SOURCE: Innovate Biopharmaceuticals, Inc. Contact: References: 2Routy, B., Le Chatelier, E., Derosa, L., Duong, C.P., Alou, M.T., Daillère, R., Fluckiger, A., Messaoudene, M., Rauber, C., Roberti, M.P. and Fidelle, M., 2018. Gut microbiome influences efficacy of PD-1–based immunotherapy against epithelial tumors. Science, 359(6371), pp.91-97. 10.1126/science.aan3706. 3Gopalakrishnan, V., Spencer, C.N., Nezi, L., Reuben, A., Andrews, M.C., Karpinets, T.V., Prieto, P.A., Vicente, D., Hoffman, K., Wei, S.C. and Cogdill, A.P., 2018. Gut microbiome modulates response to anti–PD-1 immunotherapy in melanoma patients. Science, 359(6371), pp.97-103. 10.1126/science.aan4236. |