[February 23, 2017] |
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CBT Pharmaceuticals Presents Data Demonstrating Anti-Tumor Activity of its Programmed Death-1 antibody, CBT-501, at ASCO-SITC Clinical Oncology Symposium
CBT Pharmaceuticals, Inc. (CBT), a life sciences company focused on
developing innovative oncology therapeutics, presented preclinical data
demonstrating the efficacy of its Programmed Death-1 (PD-1) antibody,
CBT-501 (genolimzumab, GB-226), in stimulating various immune cells,
generating anti-tumor immunity, and suppressing tumor growth and
delaying tumor progression in a preclinical model of colon cancer. The
data were presented in a poster at the American Society of Clinical
Oncology (ASCO) - Society for Immunotherapy of Cancer (SITC) Clinical
Immuno-Oncology Symposium being held from February 23 - 25, 2017 in
Orlando, Florida. The symposium is focused on the latest clinical and
translational research in immuno-oncology and the implications for
clinical care.
"The strong in-vivo preclinical data suggest that CBT-501 may
have clinical benefit in a variety of tumor types," said Sanjeev Redkar,
Ph.D., Chief Executive Officer and President at CBT Pharmaceuticals.
"CBT-501's novel epitope, with overlapping yet distinct regions compared
to incumbent PD-1 inhibitors, may offer a point of differentiation in
the clinical setting."
Presentation Highlights:
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CBT-501 efficiently inhibited binding of PD-L1/L2 to PD-1 through
competitive action.
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CBT-501 enhanced human T-cell activation, as shown by increased
release of IL-2 and INF-gamma.
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In a humanized preclinical model expressing human PD-1 and implanted
with a colon adenocarcinoma (MC38) cel line, CBT-501 significantly
inhibited tumor growth in a dose-dependent manner that was comparable
or improved over nivolumab.
"These studies support our commitment to advancing the clinical
development of genolimzumab as an immuno-oncology therapy for many types
of cancer. Based on these findings, a Phase 1 dose escalation and dose
and disease expansion study will be initiated in the first half of
2017," said Gavin Choy, Pharm.D., Chief Operating Officer at CBT
Pharmaceuticals.
Genolimzumab Injection (CBT-501) CBT-501 is a novel
humanized IgG4 monoclonal antibody targeting the Programmed Death-1
(PD-1) membrane receptor on T lymphocytes and other cells of the immune
system. CBT-501 has a comparable efficacy profile in in vitro and in
vivo studies to marketed anti-PD-1 antibodies and has a superior
safety profile with very low undesirable antibody-dependent
cell-mediated cytotoxicity (ADCC) and complement-dependent cytotoxicity
(CDC) activity. The antibody (GB226) has been developed by Genor
BioPharma Co. Ltd., a Walvax Company, who owns development and
commercialization rights in China. CBT Pharmaceuticals, Inc. retains
rest of the world (ROW) rights. An investigational new drug application
has been approved by the China Food and Drug Administration (CFDA), and
a phase 1 trial will be initiated in China by Genor.
About CBT Pharmaceuticals CBT Pharmaceuticals is a life
sciences company developing innovative oncology therapeutics targeting
the growth and proliferation of cancer cells. The company is advancing a
pipeline of four development-stage assets including CBT-101, an oral
c-Met inhibitor targeting the epithelial-mesenchymal transition (EMT)
pathway in cancers and CBT-501, a novel humanized monoclonal antibody
targeting the Programmed Death-1 (PD-1) membrane receptor of immune
cells, as well as two investigational products - a preclinical
multi-targeted kinase inhibitor that targets uncontrolled growth
signaling pathways and a novel humanized Programmed Death Ligand-1
(PD-L1) antibody that restores the body's immune system to recognize and
kill cancer cells. CBT is headquartered in California and has an
Australian subsidiary, CBT Pharmaceuticals (Australia) Pty Ltd to manage
all trials conducted in Australia. For additional information, please
visit: www.cbtpharma.com
View source version on businesswire.com: http://www.businesswire.com/news/home/20170223005767/en/
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