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Agent Orange exposure increases prostate cancer risk in veterans, researchers find
(Sacramento Bee, The (CA) (KRT) Via Acquire Media NewsEdge) SACRAMENTO, Calif. _ Veterans exposed to the herbicide Agent Orange are twice as likely to get prostate cancer as other veterans, University of California-Davis researchers found in a study published online by the journal Cancer.
Prostate cancer in those men also comes on earlier and is more aggressive, said Dr. Karim Chaime, chief resident in urology at UC Davis and the study's lead author.
The findings are a clear signal that men who worked with Agent Orange should be cared for differently, getting earlier biopsies and more aggressive treatment, he said.
"This is a high risk group. ... Active surveillance would probably not be a good option for these patients," Chaime said.
He described the study of more than 13,000 Northern California veterans over eight years as "the biggest study ever done" on Agent Orange effects. It will be published in the Sept. 15 print edition of Cancer, after online publication last week, and Chaime hopes it could soon lead to new VA treatment standards.
For Vietnam vet James McKasson, who participated in the study, the findings are a reminder that no one exposed to Agent Orange should delay prostate-cancer testing.
McKasson, 62, a retired auto mechanic who lives in Paradise, said he's doing well after being diagnosed with prostate cancer last year _ 40 years after he helped load Agent Orange onto planes in the 1960s.
He worked with both liquid and powdered forms of the chemical, and "this stuff would slop around; it would drip on you," he recalled. "You'd walk through it and get it on your shoes, on your clothes, on your hands. ... They didn't give us any protective clothing at all."
For decades, McKasson didn't worry much about studies that linked exposure to diseases ranging from diabetes to soft tissue cancer to birth defects in veteran's children.
"I'm an advocate now," he said, telling his "stubborn" friends to have regular checks for prostate cancer.
The chemical was used widely during the Vietnam war to defoliate jungle areas where U.S. troops believed enemies were hiding. It was also used around U.S. military facilities at home and abroad as early as the 1950s, according to the U.S. Department of Veterans Affairs.
About 375,000 men nationwide are on the military's Agent Orange registry of those exposed, and roughly one-third of them can be expected to develop prostate cancer, Chaime said.
"This has huge implications for men, especially in the VA" but also for those treated by private insurance, whose primary care doctors and urologists may not have seen the latest data, he added.
Of the 13,000 men followed by the study, just under half had been exposed to Agent Orange. Among the 6,214 men who were exposed, 239 were diagnosed with prostate cancer over eight years, compared with only 124 men out of 6,930 unexposed veterans.
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(c) 2008, The Sacramento Bee (Sacramento, Calif.).
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Copyright ? 2008 McClatchy Newspapers
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